Acta Univ. Agric. Silvic. Mendelianae Brun. 2013, 61(5), 1513-1520 | DOI: 10.11118/actaun201361051513

Bioavailability of liquid methionine hydroxy analogue-free acid relative to DL-methionine in broilers

Jiří Zelenka1, Jaroslav Heger1, Vlastislav Machander2, Markus Wiltafsky3, Martin Lešták3
1 Department of Animal Nutrition and Forage Production, Mendel University in Brno, Zemědělská 1, 613 00 Brno, Czech Republic
2 International Poultry Testing Station, Ústrašice 63, 390 02 Tábor, Czech Republic
3 Evonik Industries AG, 10 A539, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany

An experiment with broiler chickens was conducted to compare the relative bioavailability of liquid methionine hydroxy analogue free acid (MHA-FA) with that of DL-methionine (DLM) during fattening to 35 days of age. Ross 308 male chicks were allotted to 9 treatments, each consisting of six replicates of 140 birds/pen. Four graded levels (0.04, 0.08, 0.16, and 0.28 %) of MHA-FA or DLM products (weight/weight comparison) were added to a maize-wheat-soyabean meal basal diet deficient in sulphur amino acids. The criteria of response were body weight, feed conversion ratio, carcass yield and breast meat yield. Significant responses to graded levels of both methionine sources were observed in all response criteria. Using a multi-exponential model describing the dose-response relationships, the bioavailability estimates of MHA-FA relative to DLM on a weight-to-weight basis were 68, 70, 54 and 59 % for body weight, feed conversion, carcass yield and breast meat yield, respectively. If MHA-FA was compared with DLM on equimolar basis its bioavailability was 77.7, 79.0, 59.3 and 64.6 for body weight, feed conversion, carcass yield and breast meat yield, respectively. The bioavailability of MHA-FA for carcass yield and breast meat yield was significantly (P < 0.05) lower than that of DLM on a weight-to-weight and on equimolar basis.

Keywords: DLM, MHA-FA, chicken, weight gain, feed conversion, carcass yield, breast meat yield

Received: April 30, 2013; Published: September 28, 2013  Show citation

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Zelenka, J., Heger, J., Machander, V., Wiltafsky, M., & Lešták, M. (2013). Bioavailability of liquid methionine hydroxy analogue-free acid relative to DL-methionine in broilers. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 61(5), 1513-1520. doi: 10.11118/actaun201361051513
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    References

    1. AHMED, M. E., ABBAS, T. E., 2011: Effects of dietary levels of methionine on broiler performance and carcass characteristics. International Journal of Poultry Science, 10: 147-151. ISSN 0032-5791. Go to original source...
    2. BAKER, D. H., 1976: Nutritional and metabolic interrelationships among sulphur compounds in avian nutrition. Poultry Science, 35: 1917-1922. ISSN 0032-5791.
    3. BAKER, D. H., 2009: Advances in protein-amino acid nutrition of poultry. Amino Acids, 37: 29-41. ISSN 0939-4451. DOI: 10.1007/s00726-008-0198-3 Go to original source...
    4. BARTOV, I., PLAVNIK, I., 1998: Moderate excess of dietary protein increases breast meat yield of broiler chicks. Poultry Science, 77: 680-688. ISSN 0032-5791. DOI: 10.1093/ps/77.5.680 Go to original source...
    5. DILGER, R. N., BAKER, D. H., 2008: Cyst(e)ine imbalance and its effect on methionine precursor utilization in chicks. Journal of Animal Science, 86: 1832-1840. ISSN 0021-8812. DOI: 10.2527/jas.2007-0712 Go to original source...
    6. DREW, M. D., VAN KESSEL, A. G., MAENZ, D. D., 2003: Absorption of methionine and 2-hydroxy-4-methylthiobutanoic acid in conventional and germ-free chickens. Poultry Science, 82: 1149-1153. ISSN 0032-5791. DOI: 10.1093/ps/82.7.1149 Go to original source...
    7. ESTEVE-GARCIA, E., LLAURADO, L., 1997: Performance, breast meat yield and abdominal fat deposition of male broiler chickens fed diets supplemented with DL-methionine or DL-methionine hydroxy analog free acid. British Poultry Science, 38: 397-404. ISSN 0007-1668. DOI: 10.1080/00071669708418009 Go to original source...
    8. FISHER, C., MORRIS, T. R., JENNINGS, R. C., 1973: A model for the description and prediction of the response of laying hens to amino acid intake. British Poultry Science, 14: 469-484. ISSN 0007-1668. DOI: 10.1080/00071667308416054 Go to original source...
    9. FULLER, M. F., GARTHWAITE, P., 1993: The form of response of body protein accretion to dietary amino acid supply. Journal of Nutrition, 123: 957-963. ISSN 0022-3166. DOI: 10.1093/jn/123.5.957 Go to original source...
    10. HOEHLER, D., 2006. No evidence for different dose responses of commercial methionine sources in broilers. Poultry Science, 85: 2047. ISSN 0032-5791. DOI: 10.1093/ps/85.12.2047 Go to original source...
    11. HUYGHEBAERT, G., 1993: Comparison of DL-methionine and methionine hydroxy analog-free acid in broilers by using multiexponential regression models. British Poultry Science, 34: 351-359. ISSN 0007-1668. DOI: 10.1080/00071669308417590 Go to original source...
    12. JANSMAN, A. J. M., KAN, C. A., WIEBENGA, J., 2003: Comparison of the biological efficacy of DL-methionine and hydroxy-4-methylthiobutanoic acid (HMB) in pigs and poultry. ID-Lelystad No. 2209, Netherlands: Central Bureau for Livestock Feeding, Lelystad, 34 pp.
    13. KRATZER, D. D., LITTELL, R. C., 2006: Appropriate statistical methods to compare dose responses of methionine sources. Poultry Science, 85: 947-954. ISSN 0032-5791. DOI: 10.1093/ps/85.5.947 Go to original source...
    14. LEMME, A., HOEHLER, D., BRENNAN, J. J., MANNION, P. F., 2002: Relative effectiveness of methionine hydroxy analog compared to DL-methionine in broiler chickens. Poultry Science, 81: 838-845. ISSN 0032-5791. DOI: 10.1093/ps/81.6.838 Go to original source...
    15. LINGENS, G., MOLNAR, S., 1996: Studies on metabolism of broilers by using 14C-labelled DL-methionine and DL-methionine hydroxy analogue Ca-salt. Archives of Animal Nutrition, 49: 113-124. ISSN 1745-039X. Go to original source...
    16. LITTELL, R. C., HENRY, P. R., LEWIS, A. J., AMMERMAN, C. B., 1997: Estimation of relative bioavailability of nutrients using SAS procedures. Journal of Animal Science, 75: 2672-2683. ISSN 0021-8812. DOI: 10.2527/1997.75102672x Go to original source...
    17. LIU, Y. L., SONG, G. L., YI, G. F., HOU, Y. Q., HUANG, J. W., VÁZQUEZ-AŃÓN, M., KNIGHT, C. D., 2006: Effect of supplementing 2-hydroxy-4-(methylthio) butanoic acid and DL-methionine in corn-soybean-cottonseed meal diets on growth performance and carcass quality of broilers. Asian - Australasian Journal of Animal Sciences, 19: 1197-1205. DOI: 10.5713/ajas.2006.1197 Go to original source...
    18. LLAMES, C. R., FONTAINE, J., 1994: Determination of amino-acids in feeds - collaborative study. Journal of AOAC International, 77: 1362-1402. ISSN 1060-3271. Go to original source...
    19. MAENZ D. D., ENGELE-SCHAAN, C. M., 1996: Methionine and 2-hydroxy-4-methyltiobutanoic acid are partially converted to nonabsorbed compounds during passage through the small intestine and heat exposure does not affect small intestinal absorption of methionine sources in broiler chicks. Journal of Nutrition, 126: 1438-1444. ISSN 0022-3166. DOI: 10.1093/jn/126.5.1438 Go to original source...
    20. MARTÍN-VENEGAS, R., SORIANO-GARCÍA, J. F., VINARDELL, M. P., GERAERT, P. A., FERRER. R., 2006: Oligomers are not the limiting factor in the absorption of DL-2-hydroxy-4-(methylthio)butanoic acid in the chicken small intestine. Poultry Science, 85: 56-63. ISSN 0032-5791. DOI: 10.1093/ps/85.1.56 Go to original source...
    21. NAUMANN, C., BASSLER, R., SEIBOLD, R., BARTH, C., 1997: Methodenbuch Band III. VDLUFA-Darmstadt, Germany: Verlag.
    22. NOLL, S. L., WAIBEL, P. E., COOK, R. D., WITMER, J. A., 1984: Biopotency of methionine sources for young turkeys. Poultry Science, 63: 2458-2470. ISSN 0032-5791. DOI: 10.3382/ps.0632458 Go to original source...
    23. PACK, M., HOEHLER, D., LEMME, A., 2003: Economic assessment of amino acid responses in growing poultry. In: J. P. F. D'Mello (ed). Amino Acids in Animal Nutrition, CABI Publishing, Oxon: UK, pp. 459-484. Go to original source...
    24. PAYNE, R. L., LEMME, A., SEKO, H., HASHIMOTO, Y., FUJISAKI, H., KORELESKI, J., SWIATKIEWICZ, S., SZCZUREK, W., ROSTAGNO, H., 2006: Bioavailability of methionine hydroxy analog-free acid relative to DL-methionine in broilers. Animal Science Journal, 77: 427-439. ISSN 1344-3941. DOI: 10.1111/j.1740-0929.2006.00369.x Go to original source...
    25. PIEPHO, H. P., 2006: A cautionary note on appropriate statistical methods to compare dose responses of methionine sources. Poultry Science, 85: 1511-1512. ISSN 0032-5791. DOI: 10.1093/ps/85.9.1511 Go to original source...
    26. ROSS BROILER MANAGEMENT MANUAL, 2009: Aviagen, Newbridge, Midlothian, Scotland: UK. 112 pp.
    27. ROSS NUTRITION SUPPLEMENT, 2009: Aviagen, Newbridge, Midlothian, Scotland: UK. 23 pp.
    28. ROSS 308 BROILER: PERFORMANCE OBJECTIVES, 2012: Aviagen, Newbridge, Midlothian, Scotland, UK: 23 pp.
    29. SAUER, N., EMRICH, K., PIEPHO, H. P., LEMME, A., REDSHAW, M. S., MOSENTHIN, R., 2008: Meta-analysis of the relative efficiency of methionine-hydroxy-analogue-free-acid compared with DL-methionine in broilers using nonlinear mixed model. Poultry Science, 87: 2023-2031. ISSN 0032-5791. DOI: 10.3382/ps.2007-00514 Go to original source...
    30. SCHUTTE, J. B., DE JONG, J., SMINK, W., PACK, M., 1997: Replacement value of betaine for DL-methionine in male broiler chicks. Poultry Science, 76: 321-325. ISSN 0032-5791. DOI: 10.1093/ps/76.2.321 Go to original source...
    31. SCHUTTE, J. B., PACK, M., 1995: Effects of dietary sulphur containing amino acids on performance and breast deposition of broiler chicks during the growing and finishing phases. British Poultry Science, 36: 747-762. ISSN 0007-1668. DOI: 10.1080/00071669508417819 Go to original source...
    32. STILBORN, H. L., MORAN, JR., E. T., GOUS, R. M., HARRISON, M. D., 1997: Effect of age on feather amino acid content in two broiler strain crosses and sexes. Journal of Applied Poultry Research, 6: 205-209. ISSN 1056-6171. DOI: 10.1093/japr/6.2.205 Go to original source...
    33. STILBORN, H. L., MORAN, E.T. JR., GOUS, R. M., HARRISON, M. D., 2010: Influence of age on carcass (feather-free) amino acid content for two broiler strain-crosses and sexes. Journal of Applied Poultry Research, 19: 13-23. ISSN 1056-6171. DOI: 10.3382/japr.2009-00053 Go to original source...
    34. TAKAHASHI, K., AKIBA, Y., 1995: Effect of methionine supplementation on lipogenesis and lipolysis in broiler chickens. Japanese Poultry Science, 32: 99-106. DOI: 10.2141/jpsa.32.99 Go to original source...
    35. VAN WEERDEN, E. J., SCHUTTE, J. B., BERTRAM, H. L., 1992: Utilization of the polymers of methionine hydroxy analogue free acid (MHA-FA) in broiler chicks. Archiv für Geflügelkunde, 56: 63-68. ISSN 0003-9098.
    36. VÁZQUEZ-AŃÓN, M., GONZÁLEZ-ESQUERRA, R., SALEH, E., HAMPTON, T., RICTHER, S., FIRMAN, J., KNIGHT, C. D., 2006: Evidence for 2-hydroxy-4-methylthio butanoic acid and DL-methionine having a different dose-response in growing broilers. Poultry Science, 85: 1409-1420. ISSN 0032-5791. DOI: 10.1093/ps/85.8.1409 Go to original source...
    37. WALDROUP, P. W., MABRAY, C. J., BLACKMAN, J. R., SLAGTER, P. J., SHORT, R. J., JOHNSON, Z. R., 1981: Effectiveness of the free acid of methionine hydroxyanalogue as a methionine supplement in broiler diets. Poultry Science, 60, 438-443. ISSN 0032-5791. DOI: 10.3382/ps.0600438 Go to original source...
    38. WALLIS, I. R., 1999: Dietary supplements of methionine increase breast meat yield and decrease abdominal fat in growing broiler chickens. Australian Journal of Experimental Agriculture, 39: 131-141. DOI: 10.1071/EA98130 Go to original source...
    39. ZHAI, W., ARAUJO, L. F., BURGESS, S. C., COOKSEY, A. M., PENDARVIS, K., MERCIER, Y., CORZO, A., 2012: Protein expression in pectoral skeletal muscle of chickens as influenced by dietary methionine. Poultry Science, 91: 2548-2555. ISSN 0032-5791. DOI: 10.3382/ps.2012-02213 Go to original source...

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