Acta Univ. Agric. Silvic. Mendelianae Brun. 2018, 66, 815-821
Published online 2018-06-28

Overview of Bovine Dendritic Cells

Lucie Kratochvílová, Petr Sláma

Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemědělská 1, 613 00 Brno, Czech Republic

This article is an overview of dendritic cells (DCs) in cattle. The understanding of the immune system and the role of DCs in many ways can contribute to their use in the prevention and treatment of many infectious and autoimmune diseases. DCs are bone marrow-derived cells that function as professional antigen presenting cells. They act as messengers between the innate and the adaptive immune systems. The morphology of DCs results in a very large surface to volume ratio. That is, the DCs have a very large surface area compared to the overall cell volume. Currently, most dendritic cells research occurs in the human and mice. There is a lack of studies in cattle describing DCs. DCs survey the body and collect information relevant to the immune system. They are then able to instruct and direct the adaptive arms to respond to challenges.


The authors wish to express their thanks to the project of IGA AF MENDELU No. AF-IGA-IP-2018/032 for the financial support.


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