Acta Univ. Agric. Silvic. Mendelianae Brun. 2004, 52, 143-148

https://doi.org/10.11118/actaun200452020143
Published online 2015-07-03

Post-ruminal delivery systems

Miloslava Rabišková1, Jiří Třináctý2, Tomáš Sýkora1, Petr Doležal3

1Ústav technologie léků, Veterinární a farmaceutická univerzita Brno, Palackého 1-3, 61242 Brno, Česká republika
2Výzkumný ústav chovu skotu, s.r.o., Vídeňská 699, 69123 Pohořelice, Česká republika
3Ústav výživy a krmení hospodářských zvířat, Mendelova zemědělská a lesnická univerzita v Brně, Zemědělská 1, 613 00 Brno, Česká republika

Livestock industry and organization for animal wellfare underlie the need for drug and nutrient delivery systems for ruminants that protect active ingredients from ruminal fermentation. To deliver drugs or nutrients directly to the small intestine for absorption, therapeutical systems must meet the safety and cost criteria. An effective post-ruminal delivery system is a prerequisite to implement some significant advances in animal nutrition and health in ruminants. Comparing with the products developed for human use, cost constraints have impeded the development of effective post-ruminal delivery systems and rumenstable products. This article outlines physiological and technical considerations encountered in the design of effective post-ruminal delivery systems. The requirements and formulation of a pH-dependent rumen stable coating systems and possible future developments will be discussed.

References

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